Trial | NCT00159146  Report issue

Title

Trial of Pindolol Augmentation in Venlafaxine Treated Patients With Major Depression
A Short Term Double Blind Randomised Trial of Pindolol Augmentation in Venlafaxine Treated Patients With Major Depression

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Terminated

  • Study Participants

    31
This study investigates the hypothesis that pindolol can accelerate the response to antidepressants in patients with major depression treated with venlafaxine.
Antidepressant therapy has a delayed onset of action of 4-6 weeks. Pindolol has in some studies shown an accelerating effect. In this study we investigate the effect of 20 mg of pindolol retarded formulation in combination with Venlafaxine compared to placebo Pindolol and Venlafaxine for a duration of 19 days.

Effect is measured by the Hamilton Depression rating Scale and the Preskorn Scale (self-rating).
Study Started
Aug 31
2002
Study Completion
Sep 30
2007
Last Update
Dec 27
2007
Estimate

Drug Pindolol and venlafaxin

pindolol 20 mg and venlafaxin 150 mg

A Active Comparator

Venlafaxine and pindolol

B Placebo Comparator

Venlafaxin and placebo

Criteria 

Inclusion Criteria:

Major depression

Exclusion Criteria:

Allergy towards pindolol, venlafaxine or other tablet constituents
Liver or kidney impairment
Diabetics
Age below 18 years
Severe cardiac disease
Asthma.
No Results Posted