Trial | NCT00156988  Report issue

Official Title

The Effect of Two Versus Ten Days Application of Flammacerium in Partial Thickness Burns

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Indication/Condition

    Burns

  • Study Participants

    None
The objective of the proposed study is to assess whether the application of flammacerium for 2 days is as good as, or even better than, the application of flammacerium for 10 days regarding woundhealing in partial thickness burns.
Cerium is suggested to halt the cytokine cascade ensuing burn injury by binding the 'burn toxin' and, when used in combination with silver-sulfadiazine, may enhance its antibacterial effect. Since 1984, the combination of cerium and silver sulfadiazine, flammacerium, has been used in our centre. Current practice is to treat acute, non-facial, burns with daily cleaning and (re-)application of flammacerium for a total of ten days. However, prolonged application of cerium is thought to be unnecessary - it is effective in the early stages after injury- and prolonged application of silver sulfadiazine has a negative effect on wound healing. The objective of the proposed study is therefore, to assess whether the application of flammacerium for 2 days is as good as, or even better than, the application of flammacerium for 10 days regarding woundhealing in partial thickness burns.
Study Started
Mar 31
2004
Study Completion
Dec 31
2005
Last Update
Aug 10
2009
Estimate

Drug cerium nitrate-silver sulfadiazine (cerium-flamazine)

Criteria 

Inclusion Criteria:

patients having partial thickness burns with TBSA of < 10%

Exclusion Criteria:

patients not seen within 24 hours postburn
patients with only facial burns
patients with electrical or chemical burns
patients or their parents/caregivers with mental or cognitive deficits that may interfere with providing informed consent
No Results Posted