Trial | NCT00130221  Report issue

Title

Skin Cleansing With Chlorhexidine to Decrease Hospital Acquired Infections
Skin Cleansing With Chlorhexidine to Improve Nosocomial Infection Risks. (SCCIN Project)

  • Phase

    Phase 1

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    chlorhexidine ...

  • Study Participants

    208
Patients in the intensive care unit are at risk for many infections because the severity of illness and the procedures necessary to care for them. This study is designed to look at a change in bathing procedure as a method to reduce infections. Currently, patients at John H. Stroger Hospital are cleansed with soap and water. However, preliminary data from a previous study at Rush University Medical Center showed that a chlorhexidine (CHG)-impregnated cloth (2% CHG Antiseptic Cloth system, Sage Products, Inc.) decreased skin bacteria and may lessen bacteria in the blood stream. The 2% CHG Antiseptic Cloth system is a non-irritating, no-rinse, cleansing and moisturizing product that contains 2% chlorhexidine gluconate. The goal of this proposed study is to further evaluate the effectiveness of the 2% CHG Antiseptic Cloth system compared with soap and water in cleansing the skin and preventing bacteria from entering the bloodstream.
Patients admitted to the medical intensive care unit at John H Stroger Hospital are randomly assigned to Unit A or B. Unit B was randomly selected as the intervention unit. For 6 months, all patients in Unit B will be bathed with the 2% CHG Antiseptic Cloth system and all patients in Unit A will receive soap and water baths. After this 6 month period, there will be a 2 to 4 week washout period and the interventions will cross over, with Unit A receiving Chlorhexidine baths and unit B receiving soap and water for 6 months.

Each week, two randomly selected patients will have cultures of the inguinal area, neck/subclavian region, and endotracheal aspirates. A comparison of the colonization of the skin and sputum will be done between the two intervention groups.

Daily infection surveillance will be done on all patients in the intensive care unit. A comparison of blood stream infections, clinical sepsis, and other nosocomial infections will be done between the two intervention groups.
Study Started
Jun 30
2005
Primary Completion
Jun 30
2006
Study Completion
Jul 26
2006
Last Update
Jun 18
2023

Drug 2% chlorhexidine gluconate impregnated cloth

Other Daily bathing with Bar soap

bathed daily with bar soap (Dial Corp., Scottsdale, AZ), warm water, and cotton washcloths.

  • Other names: Soap

chlorhexidine gluconate (CHG) Experimental

daily skin cleansing with no-rinse, 2% CHG-impregnated cloths (Sage)

Soap & Water Active Comparator

bathing daily with bar soap (Dial Corp., Scottsdale, AZ) warm water, and cotton washcloths

Criteria 

Inclusion Criteria:

Data collection will be compiled from all the participants admitted to the Medical Intensive Care Unit (MICU).
For skin cultures: One randomly selected (intubated or non-intubated) patient in each intervention group

Exclusion Criteria:

Patients with greater than 20% of body surface area disruption in skin integrity will be excluded from participation in the 2% CHG Antiseptic Cloths arm of the study
No Results Posted