Trial | NCT00128791  Report issue

Title

Nitroprusside for Prevention of no-Reflow in Primary Angioplasty
Intracoronary Nitroprusside for the Prevention of the No-Reflow Phenomenon Following Primary Percutaneous Coronary Intervention in Acute Myocardial Infarction. A Randomized, Double Blind, Placebo-Controlled Clinical Trial

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Terminated

  • Study Participants

    100
In patients admitted with acute myocardial infarction, there is a total occlusion of a coronary artery. Even after emergency catheterization and angioplasty, in some patients, the resumed blood flow is suboptimal and impacts on heart function. The study is aimed at examining whether nitroprusside, an anti-hypertension medication, given directly into the coronary artery, can improve the blood flow after the removal of the obstruction that caused the infarction.
Inadequate myocardial tissue perfusion despite successful relief of the culprit occlusion and restoration of epicardial coronary flow for ST-segment elevation acute myocardial infarction (STEMI) results in poor outcome. The investigators hypothesized that nitroprusside (NTP) injected intracoronary immediately before angioplasty might prevent no-reflow and improve vessel flow and myocardial perfusion.
Study Started
Jan 31
2003
Study Completion
Apr 30
2005
Last Update
May 25
2007
Estimate

Drug Nitroprusside

Criteria 

Inclusion Criteria:

Acute ST elevation myocardial infarction (MI) patients planned for primary PCI
Diagnostic angiography demonstrating a TIMI flow grade <3 in the coronary artery before the PCI

Exclusion Criteria:

An admission electrocardiogram (ECG) showing complete left bundle branch block or a paced rhythm
Systolic blood pressure < 90 mmHg
A history of coronary bypass operation
A known allergic reaction to nitroprusside
Chronic hemodialysis
Intravenous drug abuse
Pregnancy
Rescue intervention after failed thrombolysis
Contraindications to aspirin or clopidogrel
Need for emergent coronary artery bypass surgery
Inability to provide informed consent
No Results Posted