Trial | NCT00115479  Report issue

Official Title

KULeuven Intensive Insulin Therapy Study in Medical Intensive Care Patients

  • Phase

    Phase 2

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    insulin human ...

  • Study Participants

    1200
In a previous study, we showed that tight blood glucose control with insulin during intensive care reduced morbidity and mortality of surgical intensive care patients. Whether this intervention also improves prognosis of medical intensive care patients remains unknown. The current prospective, randomized, controlled study will assess the impact of intensive insulin therapy on the outcome of patients in a medical intensive care unit. On admission, patients will be randomly assigned to either strict normalization of blood glucose (80-110 mg/dl) with intensive insulin therapy or the conventional approach, in which insulin infusion is initiated only when blood glucose exceeds 215 mg/dl, to maintain blood glucose levels between 180 and 200 mg/dl.
In a previous study, we showed that tight blood glucose control with insulin during intensive care reduced morbidity and mortality of surgical intensive care patients. Whether this intervention also improves prognosis of medical intensive care patients remains unknown. The current prospective, randomized, controlled study will assess the impact of intensive insulin therapy on the outcome of patients in a medical intensive care unit. On admission, patients will be randomly assigned to either strict normalization of blood glucose (80-110 mg/dl) with intensive insulin therapy or the conventional approach, in which insulin infusion is initiated only when blood glucose exceeds 215 mg/dl, to maintain blood glucose levels between 180 and 200 mg/dl.
Study Started
Mar 31
2002
Study Completion
Jun 30
2005
Last Update
May 04
2006
Estimate

Drug intensive insulin therapy to maintain normoglycemia

Criteria 

Inclusion Criteria:

Adults admitted to ICU and anticipated to require intensive care for at least a few days

Exclusion Criteria:

Expected short ICU stay
Therapy restricted upon admission
Surgical ICU patients
Other studies
Below 18 years
Pregnancy
No Results Posted