Trial | NCT00047450  Report issue

Title

Antidepressant Treatment in Older Adults With Schizophrenia
Citalopram Augmentation in Older Patients With Schizophrenia

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    citalopram ...

  • Study Participants

    212
The purpose of this study is to evaluate the safety and effectiveness of citalopram (Celexa) for the treatment of depressive symptoms in middle-aged and elderly patients with schizophrenia.
Older people with schizophrenia suffer from greater physical comorbidity, cognitive impairment, and medication side effects compared to their younger counterparts. Unfortunately, little research is available to guide the treatment of subsyndromal depressive symptoms in older adults. This study will compare the antidepressant citalopram to placebo to determine the most effective treatment for reducing depressive symptoms in older patients with schizophrenia

After patients have been on stable treatment with antipsychotic medication for at least 4 weeks, they are randomly assigned to receive antipsychotic medication plus either citalopram or placebo for 3 months. Depressive symptoms and side effects are assessed weekly for the first month, biweekly for the second month, and again at the end of the third month. Cognition, motor and daily functioning, quality of life, and medication adherence are assessed throughout the study.
Study Started
Sep 30
2001
Primary Completion
Sep 30
2006
Study Completion
Sep 30
2007
Last Update
Aug 09
2013
Estimate

Drug Citalopram (Celexa)

Citalopram for 3 months

Drug Placebo

Placebo for 3 months

1 Placebo Comparator

Participants will take placebo

2 Active Comparator

Participants will take citalopram (Celexa)

Criteria 

Inclusion Criteria:

Schizophrenia or schizoaffective disorder
HAM-D score of 8 or above
Antipsychotic medication treatment
No Results Posted