Citalopram hydrobromide (citalopram HB) belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). It is sold under the brand name Celexa and is indicated for the treatment of depression. The mechanism of action of citalopram HBr is presumed to be linked to potentiation of serotonergic activity in the central nervous system (CNS) resulting from its inhibition of CNS neuronal reuptake of serotonin (5-HT). In vitro and in vivo studies in animals suggest that citalopram is a highly selective serotonin reuptake inhibitor (SSRI) with minimal effects on norepinephrine (NE) and dopamine (DA) neuronal reuptake. Citalopram is a racemic mixture, and the inhibition of 5-HT reuptake by citalopram is primarily due to the (S)-enantiomer. Citalopram can be used off-label for the treatment of anxiety, autism, dementia, alcoholism, diabetic neuropathy, eating disorders such as anorexia and bulimia, premature ejaculation and many others. Citalopram causes dose-dependent QT interval prolongation which is why it isno longer prescribed at doses greater than 40 mg per day. NCATS
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