Related MeSH Hierarchy (4)
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Lyases » Carbon-Oxygen Lyases » Hydro-Lyases » Enoyl-CoA Hydratase 2 » Peroxisomal Multifunctional Protein-2
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Multifunctional Enzymes » Peroxisomal Multifunctional Protein-2
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Oxidoreductases » Alcohol Oxidoreductases » Hydroxysteroid Dehydrogenases » 17-Hydroxysteroid Dehydrogenases » Peroxisomal Multifunctional Protein-2
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Oxidoreductases » Alcohol Oxidoreductases » NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases » 3-Hydroxyacyl CoA Dehydrogenases » Peroxisomal Multifunctional Protein-2
Description
A dimeric protein found in liver peroxisomes that plays an important role in FATTY ACID metabolism and steroid metabolism. The dimer is formed by cleavage of a single protein precursor and contains an enoyl-CoA hydratase-2 domain and a second domain that displays (S)-3-hydroxyacyl-CoA dehydrogenase and 17-beta-estradiol dehydrogenase activities. The enzyme is stereospecific with regards to arrangement of the substrate double bonds and position of the 3-hydroxy group of the reaction intermediate. It is complemented by PEROXISOMAL BIFUNCTIONAL ENZYME, which has the opposite reaction stereospecificity. MeSH
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