Related MeSH Hierarchy (6)
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Oxidoreductases » Oxygenases » Mixed Function Oxygenases » Cytochrome P-450 Enzyme System » Steroid Hydroxylases » Sterol 14-Demethylase
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Cytochromes » Cytochrome P-450 Enzyme System » Cytochrome P450 Family 51 » Sterol 14-Demethylase
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Oxidoreductases » Oxygenases » Mixed Function Oxygenases » Cytochrome P-450 Enzyme System » Cytochrome P450 Family 51 » Sterol 14-Demethylase
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Hemeproteins » Cytochromes » Cytochrome P-450 Enzyme System » Cytochrome P450 Family 51 » Sterol 14-Demethylase
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Hemeproteins » Cytochromes » Cytochrome P-450 Enzyme System » Steroid Hydroxylases » Sterol 14-Demethylase
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Cytochromes » Cytochrome P-450 Enzyme System » Steroid Hydroxylases » Sterol 14-Demethylase
Description
An NADPH-dependent P450 enzyme that plays an essential role in the sterol biosynthetic pathway by catalyzing the demethylation of 14-methyl sterols such as lanosterol. The enzyme acts via the repeated hydroxylation of the 14-methyl group, resulting in its stepwise conversion into an alcohol, an aldehyde and then a carboxylate, which is removed as formic acid. Sterol 14-demethylase is an unusual cytochrome P450 enzyme in that it is found in a broad variety of organisms including ANIMALS; PLANTS; FUNGI; and protozoa. MeSH
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