Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Oxidoreductases » Oxygenases » Mixed Function Oxygenases
Description
Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation. MeSH
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Subtype Terms (18)
4-Hydroxybenzoate-3-Monooxygenase
Cytochrome P-450 Enzyme System
11 approved drugs
Dopamine beta-Hydroxylase
17 drugs (15 approved, 2 experimental)
gamma-Butyrobetaine Dioxygenase
Heme Oxygenase (Decyclizing)
5 drugs (4 approved, 1 experimental)
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