Frontotemporal Lobar Degeneration D057174

Related MeSH Hierarchy (4)

Diseases [C] » Nervous System Diseases [C10] » Central Nervous System Diseases » Brain Diseases » Dementia » Frontotemporal Lobar Degeneration

Diseases [C] » Nervous System Diseases [C10] » Neurodegenerative Diseases » TDP-43 Proteinopathies » Frontotemporal Lobar Degeneration

Psychiatry and Psychology [F] » Mental Disorders [F03] » Neurocognitive Disorders » Dementia » Frontotemporal Lobar Degeneration

Diseases [C] » Nutritional and Metabolic Diseases [C18] » Metabolic Diseases » Proteostasis Deficiencies » TDP-43 Proteinopathies » Frontotemporal Lobar Degeneration

Description

Heterogeneous group of neurodegenerative disorders characterized by frontal and temporal lobe atrophy associated with neuronal loss, gliosis, and dementia. Patients exhibit progressive changes in social, behavioral, and/or language function. Multiple subtypes or forms are recognized based on presence or absence of TAU PROTEIN inclusions. FTLD includes three clinical syndromes: FRONTOTEMPORAL DEMENTIA, semantic dementia, and PRIMARY PROGRESSIVE NONFLUENT APHASIA.   MeSH

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Subtype Terms (2)

Frontotemporal Dementia
20 drugs (9 approved, 11 experimental)

Primary Progressive Nonfluent Aphasia
5 drugs (1 approved, 4 experimental)


Phase 4 Indicated Drugs (1)

Phase 2 Indicated Drugs (2)


Organization Involved with Phase 4 Indications (2)

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UMLS Data


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