Diseases [C] » Nervous System Diseases [C10] » Neurodegenerative Diseases » TDP-43 Proteinopathies
Diseases [C] » Nutritional and Metabolic Diseases [C18] » Metabolic Diseases » Proteostasis Deficiencies » TDP-43 Proteinopathies
Description
Diseases characterized by the presence of abnormally phosphorylated, ubiquitinated, and cleaved DNA-binding protein TDP-43 in affected brain and spinal cord. Inclusions of the pathologic protein in neurons and glia, without the presence of AMYLOID, is the major feature of these conditions, thus making these proteinopathies distinct from most other neurogenerative disorders in which protein misfolding leads to brain amyloidosis. Both frontotemporal lobar degeneration and AMYOTROPHIC LATERAL SCLEROSIS exhibit this common method of pathogenesis and thus they may represent two extremes of a continuous clinicopathological spectrum of one disease. MeSH
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Subtype Terms (2)
Amyotrophic Lateral Sclerosis
242 drugs (108 approved, 134 experimental)
Frontotemporal Lobar Degeneration
4 drugs (3 approved, 1 experimental)
Phase 2 Indicated Drugs (3)
Organization Involved with Phase 2 Indications (6)
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