Phenomena and Processes [G] » Metabolism [G03] » Biotransformation » Inactivation, Metabolic » Metabolic Detoxication, Phase II
Phenomena and Processes [G] » Metabolism [G03] » Pharmacokinetics » Biotransformation » Inactivation, Metabolic » Metabolic Detoxication, Phase II
Phenomena and Processes [G] » Physiological Phenomena [G07] » Pharmacological and Toxicological Phenomena » Pharmacokinetics » Biotransformation » Inactivation, Metabolic » Metabolic Detoxication, Phase II
Description
The conjugation of exogenous substances with various hydrophilic substituents to form water soluble products that are excretable in URINE. Phase II modifications include GLUTATHIONE conjugation; ACYLATION; and AMINATION. Phase II enzymes include GLUTATHIONE TRANSFERASE and GLUCURONOSYLTRANSFERASE. In a sense these reactions detoxify phase I reaction products. MeSH
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