Related MeSH Hierarchy (4)
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Membrane Proteins » Receptors, Cell Surface » Receptors, Immunologic » Receptors, Cytokine » Receptors, Tumor Necrosis Factor » CD40 Antigens
Chemicals and Drugs [D] » Biological Factors [D23] » Antigens » Antigens, Surface » Antigens, Differentiation » Antigens, Differentiation, B-Lymphocyte » CD40 Antigens
Chemicals and Drugs [D] » Biological Factors [D23] » Biomarkers » Antigens, Differentiation » Antigens, Differentiation, B-Lymphocyte » CD40 Antigens
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Immune Checkpoint Proteins » CD40 Antigens
Description
Members of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. They are found on mature B-LYMPHOCYTES, some EPITHELIAL CELLS; and lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations in the CD40 antigen gene result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS. MeSH
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