Wolfram Syndrome D014929

Related MeSH Hierarchy (17)

Diseases [C] » Urogenital Diseases [C12] » Urologic Diseases » Kidney Diseases » Diabetes Insipidus » Wolfram Syndrome

Diseases [C] » Eye Diseases [C11] » Eye Diseases, Hereditary » Optic Atrophies, Hereditary » Wolfram Syndrome

Diseases [C] » Eye Diseases [C11] » Optic Nerve Diseases » Optic Atrophy » Optic Atrophies, Hereditary » Wolfram Syndrome

Diseases [C] » Eye Diseases [C11] » Vision Disorders » Blindness » Deaf-Blind Disorders » Wolfram Syndrome

Diseases [C] » Endocrine System Diseases [C19] » Diabetes Mellitus » Diabetes Mellitus, Type 1 » Wolfram Syndrome

Diseases [C] » Endocrine System Diseases [C19] » Pituitary Diseases » Diabetes Insipidus » Wolfram Syndrome

Description

A hereditary condition characterized by multiple symptoms including those of DIABETES INSIPIDUS; DIABETES MELLITUS; OPTIC ATROPHY; and DEAFNESS. This syndrome is also known as DIDMOAD (first letter of each word) and is usually associated with VASOPRESSIN deficiency. It is caused by mutations in gene WFS1 encoding wolframin, a 100-kDa transmembrane protein.   MeSH

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Phase 2 Indicated Drugs (1)

Other Experimental Indicated Drugs (1)


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Organization Involved with Phase 2 Indications (2)

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