Related MeSH Hierarchy (9)
Diseases [C] » Infections [C01] » Virus Diseases » RNA Virus Infections » Mononegavirales Infections » Paramyxoviridae Infections » Morbillivirus Infections » Measles » Subacute Sclerosing Panencephalitis
Diseases [C] » Infections [C01] » Central Nervous System Infections » Infectious Encephalitis » Encephalitis, Viral » Subacute Sclerosing Panencephalitis
Diseases [C] » Infections [C01] » Virus Diseases » Central Nervous System Viral Diseases » Encephalitis, Viral » Subacute Sclerosing Panencephalitis
Diseases [C] » Nervous System Diseases [C10] » Neuroinflammatory Diseases » Encephalitis » Infectious Encephalitis » Encephalitis, Viral » Subacute Sclerosing Panencephalitis
Diseases [C] » Infections [C01] » Central Nervous System Infections » Central Nervous System Viral Diseases » Encephalitis, Viral » Subacute Sclerosing Panencephalitis
Diseases [C] » Infections [C01] » Virus Diseases » Slow Virus Diseases » Subacute Sclerosing Panencephalitis
Diseases [C] » Nervous System Diseases [C10] » Central Nervous System Diseases » Brain Diseases » Encephalitis » Infectious Encephalitis » Encephalitis, Viral » Subacute Sclerosing Panencephalitis
Diseases [C] » Nervous System Diseases [C10] » Central Nervous System Diseases » Central Nervous System Infections » Central Nervous System Viral Diseases » Encephalitis, Viral » Subacute Sclerosing Panencephalitis
Diseases [C] » Nervous System Diseases [C10] » Central Nervous System Diseases » Central Nervous System Infections » Infectious Encephalitis » Encephalitis, Viral » Subacute Sclerosing Panencephalitis
Description
A rare, slowly progressive encephalitis caused by chronic infection with the MEASLES VIRUS. The condition occurs primarily in children and young adults, approximately 2-8 years after the initial infection. A gradual decline in intellectual abilities and behavioral alterations are followed by progressive MYOCLONUS; MUSCLE SPASTICITY; SEIZURES; DEMENTIA; autonomic dysfunction; and ATAXIA. DEATH usually occurs 1-3 years after disease onset. Pathologic features include perivascular cuffing, eosinophilic cytoplasmic inclusions, neurophagia, and fibrous gliosis. It is caused by the SSPE virus, which is a defective variant of MEASLES VIRUS. (From Adams et al., Principles of Neurology, 6th ed, pp767-8) MeSH
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