Related MeSH Hierarchy (6)
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Oxidoreductases » Oxygenases » Mixed Function Oxygenases » Cytochrome P-450 Enzyme System » Cytochrome P450 Family 11 » Steroid 11-beta-Hydroxylase
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Cytochromes » Cytochrome P-450 Enzyme System » Cytochrome P450 Family 11 » Steroid 11-beta-Hydroxylase
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Cytochromes » Cytochrome P-450 Enzyme System » Steroid Hydroxylases » Steroid 11-beta-Hydroxylase
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Oxidoreductases » Oxygenases » Mixed Function Oxygenases » Cytochrome P-450 Enzyme System » Steroid Hydroxylases » Steroid 11-beta-Hydroxylase
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Hemeproteins » Cytochromes » Cytochrome P-450 Enzyme System » Cytochrome P450 Family 11 » Steroid 11-beta-Hydroxylase
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Hemeproteins » Cytochromes » Cytochrome P-450 Enzyme System » Steroid Hydroxylases » Steroid 11-beta-Hydroxylase
Description
A mitochondrial cytochrome P450 enzyme that catalyzes the 11-beta-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11B1 gene, is important in the synthesis of CORTICOSTERONE and HYDROCORTISONE. Defects in CYP11B1 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL). MeSH
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