Chemicals and Drugs [D] » Hormones, Hormone Substitutes, and Hormone Antagonists [D06] » Hormones » Peptide Hormones » Pancreatic Hormones » Insulins » Proinsulin
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Peptides » Peptide Hormones » Pancreatic Hormones » Insulins » Proinsulin
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Protein Precursors » Proinsulin
Description
A pancreatic polypeptide of about 110 amino acids, depending on the species, that is the precursor of insulin. Proinsulin, produced by the PANCREATIC BETA CELLS, is comprised sequentially of the N-terminal B-chain, the proteolytically removable connecting C-peptide, and the C-terminal A-chain. It also contains three disulfide bonds, two between A-chain and B-chain. After cleavage at two locations, insulin and C-peptide are the secreted products. Intact proinsulin with low bioactivity also is secreted in small amounts. MeSH
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