Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Peptides » Peptide Hormones » Pancreatic Hormones » Insulins » Proinsulin » Insulin
Chemicals and Drugs [D] » Hormones, Hormone Substitutes, and Hormone Antagonists [D06] » Hormones » Peptide Hormones » Pancreatic Hormones » Insulins » Proinsulin » Insulin
Description
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). MeSH
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Phase 4 Indicated Drugs (3)
Phase 3 Indicated Drugs (2)
Phase 1 Indicated Drugs (1)
Other Experimental Indicated Drugs (13)
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