Diseases [C] » Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] » Genetic Diseases, Inborn » Skin Diseases, Genetic » Keratoderma, Palmoplantar » Papillon-Lefevre Disease
Diseases [C] » Skin and Connective Tissue Diseases [C17] » Skin Diseases » Keratosis » Keratoderma, Palmoplantar » Papillon-Lefevre Disease
Diseases [C] » Skin and Connective Tissue Diseases [C17] » Skin Diseases » Skin Diseases, Genetic » Keratoderma, Palmoplantar » Papillon-Lefevre Disease
Description
Rare, autosomal recessive disorder occurring between the first and fifth years of life. It is characterized by palmoplantar keratoderma with periodontitis followed by the premature shedding of both deciduous and permanent teeth. Mutations in the gene for CATHEPSIN C have been associated with this disease. MeSH
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