Related MeSH Hierarchy (6)
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Oxidoreductases » Oxygenases » Mixed Function Oxygenases » Cytochrome P-450 Enzyme System » Steroid Hydroxylases » Aromatase
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Cytochromes » Cytochrome P-450 Enzyme System » Cytochrome P450 Family 19 » Aromatase
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Cytochromes » Cytochrome P-450 Enzyme System » Steroid Hydroxylases » Aromatase
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Oxidoreductases » Oxygenases » Mixed Function Oxygenases » Cytochrome P-450 Enzyme System » Cytochrome P450 Family 19 » Aromatase
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Hemeproteins » Cytochromes » Cytochrome P-450 Enzyme System » Cytochrome P450 Family 19 » Aromatase
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Hemeproteins » Cytochromes » Cytochrome P-450 Enzyme System » Steroid Hydroxylases » Aromatase
Description
An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system. MeSH
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