Chemicals and Drugs [D] » Chemical Actions and Uses [D27] » Pharmacologic Actions » Therapeutic Uses » Central Nervous System Agents » Psychotropic Drugs » Antidepressive Agents » Antidepressive Agents, Tricyclic
Description
Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However, the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system. MeSH
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