Diseases [C] » Immune System Diseases [C20] » Mast Cell Activation Disorders
Description
A spectrum of primary, secondary, and idiopathic disorders involving MAST CELLS and characterized by an aberrant release of mast cell mediators which result in multiple and variable inflammatory and allergic symptoms. These disorders are associated with various mutations in tyrosine kinase KIT (PROTO-ONCOGENE PROTEINS C-KIT) and other genes, underlying conditions, and responses to allergic or non-allergic triggers of mast cell stimulation and degranulation such as local anesthetics, lactam antibiotics, muscle relaxants, specific foods, environmental toxins, physical conditions such as vibration, cold, pressure, and stress. MeSH
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Subtype Terms (2)
Mast Cell Activation Syndrome
2 experimental drugs
Mastocytosis
24 drugs (15 approved, 9 experimental)
Phase 2 Indicated Drugs (2)
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UMLS Data
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