Related MeSH Hierarchy (5)
Chemicals and Drugs [D] » Organic Chemicals [D02] » Amides » Lactams » beta-Lactams » Carbapenems » Thienamycins » Imipenem » Cilastatin, Imipenem Drug Combination
Chemicals and Drugs [D] » Organic Chemicals [D02] » Hydrocarbons » Hydrocarbons, Cyclic » Hydrocarbons, Alicyclic » Cycloparaffins » Cyclopropanes » Cilastatin » Cilastatin, Imipenem Drug Combination
Chemicals and Drugs [D] » Heterocyclic Compounds [D03] » Heterocyclic Compounds, Fused-Ring » Heterocyclic Compounds, 2-Ring » beta-Lactams » Carbapenems » Thienamycins » Imipenem » Cilastatin, Imipenem Drug Combination
Chemicals and Drugs [D] » Lipids [D10] » Fatty Acids » Fatty Acids, Unsaturated » Fatty Acids, Monounsaturated » Cilastatin » Cilastatin, Imipenem Drug Combination
Chemicals and Drugs [D] » Pharmaceutical Preparations [D26] » Drug Combinations » Cilastatin, Imipenem Drug Combination
Description
Combination of imipenem and cilastatin that is used in the treatment of bacterial infections; cilastatin inhibits renal dehydropeptidase I to prolong the half-life and increase the tissue penetration of imipenem, enhancing its efficacy as an anti-bacterial agent. MeSH
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