Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Nuclear Proteins » Fanconi Anemia Complementation Group N Protein
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Fanconi Anemia Complementation Group Proteins » Fanconi Anemia Complementation Group N Protein
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Neoplasm Proteins » Tumor Suppressor Proteins » Fanconi Anemia Complementation Group N Protein
Description
A Fanconi anemia complementation group protein that contains an N-terminal DNA-binding region and seven, C-terminal, WD REPEATS. It is an essential factor in HOMOLOGOUS RECOMBINATION DNA REPAIR through its interactions with BRCA2 PROTEIN; RAD51 RECOMBINASE; and BRCA1 PROTEIN. It functions as a molecular scaffold to localize and stabilize these proteins at homologous recombination sites. Mutations in the PALB2 gene are associated with FANCONI ANEMIA complementation group N; type 3 PANCREATIC NEOPLASMS; and susceptibility to BREAST CANCER. MeSH
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