Related MeSH Hierarchy (4)
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Peptides » Intracellular Signaling Peptides and Proteins » Inhibitor of Growth Protein 1
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Intracellular Signaling Peptides and Proteins » Inhibitor of Growth Protein 1
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Neoplasm Proteins » Tumor Suppressor Proteins » Inhibitor of Growth Protein 1
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Nuclear Proteins » Inhibitor of Growth Protein 1
Description
A nuclear protein and tumor suppressor that contains a C-terminal PHD ZINC FINGER. It is expressed in different isoforms in various tissues and interacts with TUMOR SUPPRESSOR PROTEIN P53 to negatively regulate cell growth. Reduced expression and chromosomal rearrangements of the ING1 gene are associated with different cancers including HEAD AND NECK NEOPLASMS. MeSH
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