Phenomena and Processes [G] » Chemical Phenomena [G02] » Biochemical Phenomena » Molecular Structure » Molecular Conformation » Protein Conformation » Protein Structural Elements » Amino Acid Motifs » Zinc Fingers » PHD Zinc Fingers
Description
Zinc finger domains of approximately 50 to 80 amino acids in length that are characterized by a conserved Cysteine(3)-Histidine-Cysteine(4) amino acid motif which coordinates binding of two zinc ions. They are similar structurally to RING FINGER DOMAINS, with a globular fold topology of two BETA-SHEETS and an ALPHA-HELIX. PHD fingers occur in many proteins that function in chromatin-mediated gene expression and EPIGENETICS such as POLYCOMB-GROUP PROTEINS. MeSH
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