Prion Proteins D000072002

Related MeSH Hierarchy (4)

Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Glycoproteins » Membrane Glycoproteins » GPI-Linked Proteins » Prion Proteins

Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Membrane Proteins » Lipid-Linked Proteins » GPI-Linked Proteins » Prion Proteins

Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Membrane Proteins » Membrane Glycoproteins » GPI-Linked Proteins » Prion Proteins

Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Prions » Prion Proteins

Description

Membrane glycosylphosphatidylinositol-anchored glycoproteins that may aggregate into rod-like structures. The prion protein (PRNP) gene is characterized by five TANDEM REPEAT SEQUENCES that encode a highly unstable protein region of five octapeptide repeats. Mutations in the repeat region and elsewhere in this gene are associated with CREUTZFELDT-JAKOB DISEASE; FATAL FAMILIAL INSOMNIA; GERSTMANN-STRAUSSLER DISEASE; Huntington disease-like 1, and KURU.   MeSH

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