Active Ingredient History

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Levofloxacin is the L-isomer of the racemate, ofloxacin, a quinolone antimicrobial agent. Levofloxacin is used for oral and intravenous administration. Levofloxacin is sold under brand name levaquin and is used to treat infections in adults (≥18 years of age) caused by designated, susceptible bacteria such as, pneumonia: nosocomial and community acquired; skin and skin structure infections: complicated and uncomplicated; chronic bacterial prostatitis; inhalational anthrax. In addition this drug is used to treat plague; urinary tract infections: complicated and uncomplicated; acute pyelonephritis; acute bacterial exacerbation of chronic bronchitis and acute bacterial sinusitis. Levofloxacin, like other fluoroquinolones, inhibits the bacterial DNA gyrase, halting DNA replication. This results in strand breakage on a bacterial chromosome, supercoiling, and resealing. In addition, levofloxacin inhibits a bacterial type II topoisomerase.   NCATS

  • SMILES: C[C@H]1COC2=C(N3CCN(C)CC3)C(F)=CC4=C2N1C=C(C(O)=O)C4=O
  • InChIKey: GSDSWSVVBLHKDQ-JTQLQIEISA-N
  • Mol. Mass: 361.3675
  • ALogP: 1.54
  • ChEMBL Molecules:
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Drug Pricing (per unit)

United States

$0.1533 - $21.2000
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Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Combination drugs

(3s)-(-)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid | de-108 | dr-3355 | evoxil | floxacin | iquix | levaquin | levoflocaxin | levofloxacin | levofloxacin anhydrous | levofloxacine | levofloxacin hydrate | levofloxacino | levofloxacinum | l-ofloxacin | norphloxacine | oftaquix | quinsair | quixin | rwj-25213 | (s)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7h-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid | (s)-(-)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de][1,4]benzooxazine-6-carboxylic acid | tavanic

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