Active Ingredient History
Acetylcholine is the neurotransmitter at neuromuscular junctions, at synapses in the ganglia of the visceral motor system, and at a variety of sites within the central nervous system. Whereas a great deal is known about the function of cholinergic transmission at the neuromuscular junction and at ganglionic synapses, the actions of acetylcholine in the central nervous system are not as well understood. Cholinergic system is an important system and a branch of the autonomic nervous system which plays an important role in memory, digestion, control of heart beat, blood pressure, movement and many other functions. Acetylcholine in the brain alters neuronal excitability, influences synaptic transmission, induces synaptic plasticity, and coordinates firing of groups of neurons. Miochol®-E (acetylcholine chloride intraocular solution) is used to obtain miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required. NCATS
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Anemia (Phase 2)
Anemia, Sickle Cell (Phase 2)
Anesthesia and Analgesia (Early Phase 1)
Breast Neoplasms (Phase 1/Phase 2)
Coronary Artery Disease (Phase 1)
Diabetes, Gestational (Early Phase 1)
Diabetes Mellitus, Type 2 (Phase 2)
Endothelial Cells (Phase 1/Phase 2)
Graft Rejection (Phase 1)
Healthy Volunteers (Phase 4)
Heart Failure (Phase 1)
HIV (Phase 1)
Hyperlipidemias (Phase 2)
Hypertension (Phase 1)
Hypertension, Pulmonary (Phase 1)
Inflammation (Phase 1)
Insulin (Phase 2)
Ischemia (Phase 1)
Leukemia (Phase 1/Phase 2)
Livedoid Vasculopathy (Phase 1)
Lymphoma (Phase 1/Phase 2)
Obesity (Early Phase 1)
Oxidative Stress (Phase 1)
Pre-Eclampsia (Early Phase 1)
Pulmonary Disease, Chronic Obstructive (Phase 1)
Vascular Diseases (Phase 1/Phase 2)
Vascular Stiffness (Early Phase 1)
Vasoconstriction (Early Phase 1)
Vasodilation (Early Phase 1)
| Trial | Phase | Start Date | Organizations | Indications |
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