droxidopa (northera) Report issue

Small molecule Orphan Drug FDA Approved FDA Fast Track FDA Accelerated Approval FDA Priority Review FDA

Active Ingredient History

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Droxidopa (Northera, Chelsea Therapeutics) is a synthetic catecholamino acid precursor of norepinephrine indicated for the treatment of orthostatic dizziness or lightheadedness in adult patients with symptomatic neurogenic orthostatic hypotension (NOH) caused by primary autonomic failure, dopamine beta-hydroxylase deficiency, and non-diabetic autonomic neuropathy. Droxidopa was approved as oral therapy in February 2014 under the FDA’s accelerated approval program. Droxidopa is directly metabolized to norepinephrine by dopadecarboxylase. The specific mechanism of action of the drug is not known completely, but it is supposed to exert the pharmacological effects through norepinephrine and not through the parent molecule or other metabolites. It increases blood flow to the brain by stimulating peripheral arterial and venous vasoconstriction.   NCATS

  • SMILES: N[C@@H]([C@H](O)C1=CC=C(O)C(O)=C1)C(O)=O
  • InChIKey: QXWYKJLNLSIPIN-JGVFFNPUSA-N
  • Mol. Mass: 213.1873
  • ALogP: -0.46
  • ChEMBL Molecule:
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Drug Pricing (per unit)

United States

$1.0578 - $85.1717
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Note: This drug pricing data is preliminary, incomplete, and may contain errors.

dihydroxyphenylserine | dops | droxidopa | l-dihydroxyphenylserine | l-dops | l-threo | l-threo-3,4-dihydroxyphenylserine | l-threo-dihydroxyphenylserine | l-threo dops | northera | threo-dopaserine

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