didanosine (videx) Report issue

Small molecule Approved FDA Priority Review FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Didanosine was developed by Bristol-Myers Squibb in collaboration with the NIH for the treatment of HIV-1 infections. Upon administration the drug is metabolized to the active metabolite which inhibits HIV-1 reverse transcriptase both by competing with deoxyadenosine 5'-triphosphate and by its incorporation into viral DNA. Didanosine was approved by FDA under the name Videx (among the other names).   NCATS

Chemistry

  • SMILES: OC[C@@H]1CC[C@@H](O1)N2C=NC3=C2N=CNC3=O
  • InChIKey: BXZVVICBKDXVGW-NKWVEPMBSA-N
  • Mol. Mass: 236.2273
  • ALogP: -0.21
  • ChEMBL Molecule:
    didanosine  
More Chemistry

Pharmacology

Alternative names

2,3-dideoxyinosine | 2',3'-dideoxyinosine | 9-[(2r,5s)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,9-dihydro-6h-purin-6-one | 9-((2r,5s)-5-hydroxymethyl-tetrahydro-furan-2-yl)-1,9-dihydro-purin-6-one | 9-((2r,5s)-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-1h-purin-6(9h)-one | 9-((2s,5r)-5-hydroxymethyl-tetrahydro-furan-2-yl)-9h-purin-6-ol | bmy-40900 | ddi | ddino | didanosina | didanosine | didanosinum | dideoxyinosine | dideoxyinosine (ddi) | videx | videx ec

Organizations (73)

Research & Development (69)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (5)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (18)

Approved Indications (1)


 

HIV Infections

Experimental Indications - Clinical Trial Phases 1-4 (18)


 

Acquired Immunodeficiency Syndrome (Phase 3)

AIDS Dementia Complex (Phase 2)

AIDS-Related Complex (Phase 3)

Antiretroviral Therapy, Highly Active (Phase 2)

Brain Diseases (Phase 2)

Cardiovascular Diseases (Phase 4)

Cytomegalovirus Infections (Phase 1)

Hemophilia A (Phase 4)

Hepatitis C (Phase 1)

HIV (Phase 4)

HIV-Associated Lipodystrophy Syndrome (Phase 4)

HIV Infections ()

Leukoencephalopathy, Progressive Multifocal (Phase 2)

Lymphoma (Phase 2)

Mycobacterium avium-intracellulare Infection (Phase 1)

Pregnancy (Phase 1)

Sarcoma, Kaposi (Phase 2)

Tuberculosis (Phase 3)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 134
  • # of Trial Organizations: 69

Trials by Phase

Trial Phase Start Date Organizations Indications

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