Related MeSH Hierarchy (11)
Diseases [C] » Nervous System Diseases [C10] » Demyelinating Diseases » Leukoencephalopathy, Progressive Multifocal
Diseases [C] » Nervous System Diseases [C10] » Central Nervous System Diseases » Central Nervous System Infections » Infectious Encephalitis » Encephalitis, Viral » Leukoencephalopathy, Progressive Multifocal
Diseases [C] » Nervous System Diseases [C10] » Central Nervous System Diseases » Central Nervous System Infections » Central Nervous System Viral Diseases » Encephalitis, Viral » Leukoencephalopathy, Progressive Multifocal
Diseases [C] » Nervous System Diseases [C10] » Neuroinflammatory Diseases » Encephalitis » Infectious Encephalitis » Encephalitis, Viral » Leukoencephalopathy, Progressive Multifocal
Diseases [C] » Infections [C01] » Central Nervous System Infections » Central Nervous System Viral Diseases » Encephalitis, Viral » Leukoencephalopathy, Progressive Multifocal
Diseases [C] » Infections [C01] » Central Nervous System Infections » Infectious Encephalitis » Encephalitis, Viral » Leukoencephalopathy, Progressive Multifocal
Diseases [C] » Infections [C01] » Virus Diseases » Central Nervous System Viral Diseases » Encephalitis, Viral » Leukoencephalopathy, Progressive Multifocal
Diseases [C] » Infections [C01] » Virus Diseases » DNA Virus Infections » Polyomavirus Infections » Leukoencephalopathy, Progressive Multifocal
Diseases [C] » Infections [C01] » Virus Diseases » Slow Virus Diseases » Leukoencephalopathy, Progressive Multifocal
Diseases [C] » Nervous System Diseases [C10] » Central Nervous System Diseases » Brain Diseases » Encephalitis » Infectious Encephalitis » Encephalitis, Viral » Leukoencephalopathy, Progressive Multifocal
Diseases [C] » Nervous System Diseases [C10] » Central Nervous System Diseases » Brain Diseases » Leukoencephalopathies » Leukoencephalopathy, Progressive Multifocal
Description
An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7) MeSH
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Approved Indicated Drugs (1)
Phase 4 Indicated Drugs (2)
Phase 1 Indicated Drugs (1)
Other Experimental Indicated Drugs (3)
Organization Involved with Phase 4 Indications (2)
Organization Involved with Phase 2 Indications (9)
Organization Involved with Phase 1 Indications (1)
Organization Involved with Other Experimental Indications (1)
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UMLS Data
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