Active Ingredient History
Prilocaine is a local anesthetic that is similar pharmacologically to lidocaine. Prilocaine binds to the intracellular surface of sodium channels which blocks the subsequent influx of sodium into the cell. Action potential propagation and never function is, therefore, prevented. This block is reversible and when the drug diffuses away from the cell, sodium channel function is restored and nerve propagation returns. Prilocaine acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers. Currently, Prilocaine is used most often for infiltration anesthesia in dentistry. NCATS
Combination drugs
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Acne Vulgaris (Phase 4)
Acute Pain (Phase 4)
Analgesia (Phase 3)
Anesthesia (Phase 4)
Anesthesia and Analgesia (Phase 4)
Anesthesia, Dental (Phase 1)
Anesthesia, Local (Phase 4)
Anesthesia, Spinal (Phase 4)
Anesthetics, Local (Phase 2)
Arthropathy, Neurogenic (Phase 4)
Arthroscopy (Phase 4)
beta-Thalassemia (Phase 2)
Bone Marrow Diseases (Phase 3)
Bowen's Disease (Phase 1)
Brachial Plexus Block (Phase 4)
Bursitis (Phase 4)
Carcinoma, Squamous Cell (Phase 1)
Cataract (Phase 1/Phase 2)
Cicatrix (Phase 4)
Cognitive Dysfunction (Phase 1/Phase 2)
Contraception (Phase 4)
Dermatology (Phase 2/Phase 3)
Diabetes Mellitus (Phase 3)
Drug Delivery Systems (Phase 1)
Drug-Related Side Effects and Adverse Reactions (Phase 2/Phase 3)
Ecthyma (Phase 2)
Family Planning Services (Phase 4)
Fractures, Closed (Phase 4)
General Surgery (Phase 4)
Genital Diseases, Female (Phase 4)
Glaucoma (Phase 1/Phase 2)
Healthy Volunteers (Phase 4)
Hemodynamics (Phase 3)
Hemorrhoidectomy (Phase 2/Phase 3)
Hemorrhoids (Phase 4)
Hernia, Inguinal (Phase 4)
Hidradenitis Suppurativa (Early Phase 1)
Hypotension (Phase 3)
Intrauterine Devices (Phase 2)
Keratosis, Actinic (Phase 4)
Lacerations (Phase 4)
Leg Ulcer (Phase 2)
Leukemia (Phase 4)
Lung Diseases (Phase 4)
Lymphoma (Phase 4)
Lymphoma, Non-Hodgkin (Phase 4)
Memory Disorders (Phase 1/Phase 2)
Meningioma (Phase 4)
Neoplasms (Phase 2)
Nerve Block (Phase 4)
Neuralgia, Postherpetic (Phase 2)
Osteoarthritis, Hip (Phase 4)
Osteoarthritis, Knee (Phase 4)
Pain ()
Pain, Postoperative (Phase 4)
Paralysis (Phase 4)
Periodontal Diseases (Phase 4)
Pharmacokinetics (Early Phase 1)
Phlebotomy (Early Phase 1)
Pregnancy Complications (Phase 4)
Pregnant Women (Phase 3)
Premature Ejaculation (Phase 2/Phase 3)
Prostatic Neoplasms (Phase 4)
Psoriasis (Phase 3)
Quality of Life (Phase 2/Phase 3)
Radial Artery (Phase 4)
Rectal Fistula (Phase 4)
Rhytidoplasty (Phase 4)
Sclerosis (Phase 3)
Tattooing (Phase 4)
Tinnitus (Phase 4)
Tooth (Phase 4)
Tooth Extraction (Phase 4)
Varicose Ulcer (Phase 2)
Vulvar Diseases (Phase 4)
Wounds and Injuries (Phase 2)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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