Active Ingredient History

NOW
  • Now
Reserpine is an alkaloid, isolated from the Rauwolfia serpentina plant and developed by Ciba pharma. Reserpine was approved by FDA for the treatment of hypertension and psychotic disorders. The drug exerts its effect by blocking two vesicular monoamine transporters, VMAT1 and VMAT2. The blockade results in vesicles that lose their ability to store neurotransmitter molecules. Neurotransmitters, thus retained in cytosol, are then neutralized by MAO.   NCATS

  • SMILES: CO[C@H]1[C@@H](C[C@@H]2CN3CCC4=C(NC5=C4C=CC(OC)=C5)[C@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)C6=CC(OC)=C(OC)C(OC)=C6
  • InChIKey: QEVHRUUCFGRFIF-MDEJGZGSSA-N
  • Mol. Mass: 608.6787
  • ALogP: 4.17
  • ChEMBL Molecules:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Discontinued
  • Delivery Methods: Oral
  • Pro Drug: No

Combination drugs

( chlorthalidone (Hygroton), reserpine (serpasil) - other name: regroton )
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( reserpine (serpasil), chlorothiazide (diuril) - other name: chlorothiazide-reserpine )
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( reserpine (serpasil), hydroflumethiazide (saluron) - other name: salutensin-demi )
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( hydralazine (apresoline), hydrochlorothiazide (esidrix), reserpine (serpasil) - other names: cam-ap-es, hydralazine, hydrochlorothiazide w/ reserpine, hydrap-es )
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( hydralazine (apresoline), reserpine (serpasil) - other name: dralserp )
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( hydrochlorothiazide (esidrix), reserpine (serpasil) - other names: h.r, hydropres, hydro-reserp, reserpine and hydrochlorothiazide )
3,4,5-trimethoxybenzoyl methyl reserpate | (3beta,16beta,17alpha,18beta,20alpha)-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester | apoplon | deserpine | elserpine | hiserpia | raudixin | rau-sed | rauval | rauwasedin | reserpin | reserpine | (-)-reserpine | (−)-reserpine | rivasin | sandril | serpalan | serpanray | serpasil | serpate | serpine | serpivite

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