chlorthalidone (Hygroton) Report issue

Small molecule Approved FDA Priority Review FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Chlorthalidone is a diuretic that is used for the treatment of hypertansion and edema. The drug is approved by FDA and either prescribed alone (Chlorthalidone trade name) or in combination with atenolol (Tenoretic trade name), azilsartan kamedoxomil (Edarbyclor) and clonidin (Clorpres). The mechanism of action is associated with activation of sodium and chloride renal excretion.   NCATS

Chemistry

  • SMILES: NS(=O)(=O)C1=C(Cl)C=CC(=C1)C2(O)NC(=O)C3=CC=CC=C23
  • InChIKey: JIVPVXMEBJLZRO-UHFFFAOYSA-N
  • Mol. Mass: 338.766
  • ALogP: 0.92
  • ChEMBL Molecule:
    chlorthalidone  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Oral
  • Pro Drug: No

Drug Pricing (per unit)

United States

$0.1878 - $0.5879
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Combination drugs

( chlorthalidone (Hygroton), clonidine (catapres) - other name: clorpres )
|
( chlorthalidone (Hygroton), reserpine (serpasil) - other name: regroton )
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( azilsartan (edarbi), chlorthalidone (Hygroton) )
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( chlorthalidone (Hygroton), betaxolol (kerlone) )
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( chlorthalidone (Hygroton), metoprolol (lopressor) )
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( chlorthalidone (Hygroton), atenolol (tenormin) )

Alternative names

1-keto-3-(3'-sulfamyl-4'-chlorophenyl)-3-hydroxyisoindoline | 1-oxo-3-(3-sulfamyl-4-chlorophenyl)-3-hydroxyisoindoline | 2-chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl)benzenesulfonamide | 2-chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1h-isoindol-1-yl)benzenesulfonamide | 3-(4'-chloro-3'-sulfamoylphenyl)-3-hydroxyphthalimidine | 3-hydroxy-3-(4-chloro-3-sulfamylphenyl)phthalimidine | chlorotalidone | chlorphthalidolone | chlortalidone | chlorthalidon | chlorthalidone | clortalidone | g-33182 | hygroton | phthalamodine | phthalamudine | thalitone

Organizations (130)

Research & Development (75)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (56)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Overview

  • Highest Phase: Phase 4
  • # of Trials: 73
  • # of Trial Organizations: 75

Trials by Phase

Trial Phase Start Date Organizations Indications

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