polymyxin b sulfate (poly-rx) Report issue

Small molecule Approved FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Polymyxin B is a lipopeptide antibiotic isolated from Bacillus polymyxa. Its basic structure consists of a polycationic peptide ring and a tripeptide side chain with a fatty acid tail. Polymyxin B is a mixture of at least four closely related components, polymyxin B1 to B4, with polymyxin B1 and B2 being the two major components. Polymyxin B acts on Gram-negative bacteria by interacting with lipopolysaccharide (LPS) of the outer membrane and destabilizing it. Polymyxin B is indicated for the treatment of many bacterial diseases such as meningeal infections, urinary tract infections and bacteremia.   NCATS

Chemistry

More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Missing data
  • Pro Drug: No

Drug Pricing (per unit)

United States

$50.2500
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Combination drugs

( urea, neomycin, polymyxin b sulfate (poly-rx) - other names: neomycin and polymyxin b sulfates and hydrocortisone, oticair, pediotic )
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( chloramphenicol (chloromycetin), polymyxin b sulfate (poly-rx) )
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( urea, bacitracin (polysporin), neomycin, polymyxin b sulfate (poly-rx) - other names: bacitracin-neomycin-polymyxin w/ hydrocortisone acetate, neomycin and polymyxin b sulfates, bacitracin zinc and hydrocortisone )
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( lidocaine (xylocaine), bacitracin (polysporin), neomycin, polymyxin b sulfate (poly-rx) )
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( neomycin, polymyxin b sulfate (poly-rx), dexamethasone - other names: dexacidin, dexasporin, neomycin and polymyxin b sulfates and dexamethasone )
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( bacitracin (polysporin), neomycin, polymyxin b sulfate (poly-rx) - other name: neomycin and polymyxin b sulfates and bacitracin zinc )
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( neomycin, polymyxin b sulfate (poly-rx), gramicidin - other name: neomycin and polymyxin b sulfates and gramicidin )
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( neomycin, polymyxin b sulfate (poly-rx) - other names: neomycin and polymyxin b sulfate, statrol )
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( urea, chloramphenicol (chloromycetin), polymyxin b sulfate (poly-rx) )
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( prednisone (meticorten), neomycin, polymyxin b sulfate (poly-rx) )
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( bacitracin (polysporin), polymyxin b sulfate (poly-rx) )
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( trimethoprim, polymyxin b sulfate (poly-rx) )
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( urea, polymyxin b sulfate (poly-rx) - other name: otobiotic )
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( polymyxin b sulfate (poly-rx), oxytetracycline (terramycin) )

Alternative names

aerosporin | bacitracin - polymyxin b | bacitracin, polymyxin b drug combination | duobiotic | gppe pdr ster | mastimyxin | neosporin | polimixina b | polyfax | polymycin b sulfate | polymyxin | polymyxin b | polymyxin b(1) | polymyxin-b-sulfat | polymyxin b sulfate | polymyxin b sulphate | polymyxine b | polymyxine b (sulfate de) | polymyxini b sulfas | polymyxinum b | poly-rx | polysporin | polytrim | thiosporin

Organizations (94)

Research & Development (52)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (43)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (37)

Approved Indications (7)


 

Bacteremia (approved 1964)

Infections

Inflammation

Meningitis, Haemophilus (approved 1964)

Pneumonia

Pseudomonas Infections (approved 1964)

Urinary Tract Infections (approved 1964)

Experimental Indications - Clinical Trial Phases 1-4 (32)


 

Anesthesia and Analgesia (Phase 3)

Bacteremia (Phase 2/Phase 3)

Bacterial Infections (Early Phase 1)

Burns (Phase 2/Phase 3)

Conjunctivitis (Phase 4)

Conjunctivitis, Bacterial (Phase 3)

Critical Illness (Phase 3)

Cross Infection (Phase 4)

Dentures (Phase 1)

Diabetic Foot (Phase 2)

Drug Evaluation (Phase 3)

Drug-Related Side Effects and Adverse Reactions (Phase 1)

Drug Resistance, Bacterial (Phase 3)

Eczema (Phase 3)

Edema (Phase 2/Phase 3)

Graft vs Host Disease (Phase 2)

Healthcare-Associated Pneumonia (Phase 2/Phase 3)

Heart Failure (Phase 3)

Hematopoietic Stem Cell Transplantation (Phase 2)

Hordeolum (Phase 3)

Kidney Failure, Chronic (Phase 4)

Leber Congenital Amaurosis (Phase 1/Phase 2)

Nasolacrimal Duct (Phase 1)

Otitis (Phase 3)

Pneumonia, Ventilator-Associated (Phase 2/Phase 3)

Retinoblastoma (Phase 1)

Sick Sinus Syndrome (Phase 3)

Syncope (Phase 3)

Urinary Tract Infections (Phase 4)

Vaginitis (Phase 4)

Wound Healing (Phase 2)

Wounds and Injuries (Phase 3)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 35
  • # of Trial Organizations: 52

Trials by Phase

Trial Phase Start Date Organizations Indications

Feedback

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