dihydrocodeine Report issue

Small molecule Approved FDA
AACT ChEMBL DrugBank Drug Central KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Dihydrocodeine is an opioid analgesic used as an alternative or adjunct to codeine to treat moderate to severe pain, severe dyspnea, and cough. It is semi-synthetic, and was developed in Germany in 1908 during an international search to find a more effective antitussive agent to help reduce the spread of airborne infectious diseases such as tuburculosis. It was marketed in 1911. Dihydrocodeine is metabolized to dihydromorphine -- a highly active metabolite with a high affinity for mu opioid receptors. Dihydrocodeine is used for the treatment of moderate to severe pain, including post-operative and dental pain. It can also be used to treat chronic pain, breathlessness and coughing. In heroin addicts, dihydrocodeine has been used as a substitute drug, in doses up to 2500mg/day to treat addiction.   NCATS

Chemistry

  • SMILES: COc1ccc2c3c1O[C@H]1[C@@H](O)CC[C@H]4[C@@H](C2)N(C)CC[C@@]341
  • InChIKey: RBOXVHNMENFORY-DNJOTXNNSA-N
  • Mol. Mass: 301.39
  • ALogP: 1.73
  • ChEMBL Molecules:
    dihydrocodeine  
    dihydrocodeine bitartrate  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Oral
  • Pro Drug: No

Combination drugs

( acetaminophen (tylenol), caffeine, dihydrocodeine - other names: synalgos-dc-a, trezix )
|
( caffeine, acetylsalicylic acid (aspirin), dihydrocodeine )

Alternative names

codhydrine | cohydrin | contugesic | dehacodin | df 118 | df-118 | dhc | dhc continus | dhc mundipharma | dicodin | dihydric | dihydrocodeine | dihydrocodeine, (5alpha,6alpha,14alpha)-isomer | dihydrocodeine, (5alpha,6beta,14alpha)-isomer | dihydrocodeine, (5alpha,6beta)-isomer | dihydrocodeine acetate, (5alpha,6alpha)-isomer | dihydrocodeine bitartrate | dihydrocodeine hydrochloride, (5alpha,6alpha)-isomer | dihydrocodeine phosphate | dihydrocodeine phosphate (1:1), (5alpha,6alpha)-isomer | dihydrocodeine tartrate (1:1), (5alpha,6alpha)-(r-(r*,r*))-isomer | dihydrocodeine tartrate (1:1), (5alpha,6beta)-(r-(r*,r*))-isomer | dihydrocodeine, thiocyanate salt (5alpha,6alpha)-isomer | dihydroneopine | drocode | hydrocodeine | hydrocodin | paracodin | paracodina | paramol 118 | parzone bitartrate | remedacen | rikodeine | tiamon | tosidrin

Organizations (13)

Research & Development (4)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (9)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (1)

Approved Indications (1)


 

Pain

Experimental Indications - Clinical Trial Phases 1-4 (1)


 

Pain (Phase 4)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 2
  • # of Trial Organizations: 4

Trials by Phase

Trial Phase Start Date Organizations Indications

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