Active Ingredient History

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Caffeine is a methylxanthine alkaloid found in the seeds, nuts, or leaves of a number of plants native to South America and East Asia that is structurally related to adenosine and acts primarily as an adenosine receptor antagonist with psychotropic and anti-inflammatory activities. Upon ingestion, caffeine binds to adenosine receptors in the central nervous system (CNS), which inhibits adenosine binding. This inhibits the adenosine-mediated downregulation of CNS activity; thus, stimulating the activity of the medullary, vagal, vasomotor, and respiratory centers in the brain. The anti-inflammatory effects of caffeine are due the nonselective competitive inhibition of phosphodiesterases. Caffeine is used by mouth or rectally in combination with painkillers (such as aspirin and acetaminophen) and a chemical called ergotamine for treating migraineheadaches. It is also used with painkillers for simple headaches and preventing and treating headaches after epidural anesthesia. Caffeine creams are applied to the skin to reduce redness and itching in dermatitis. Healthcare providers sometimes give caffeine intravenously (by IV) for headache after epidural anesthesia, breathing problems in newborns, and to increase urine flow. In foods, caffeine is used as an ingredient in soft drinks, energy drinks, and other beverages.   NCATS

  • SMILES: CN1C(=O)N(C)c2ncn(C)c2C1=O
  • InChIKey: RYYVLZVUVIJVGH-UHFFFAOYSA-N
  • Mol. Mass: 194.19
  • ALogP: -1.03
  • ChEMBL Molecules:
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Drug Pricing (per unit)

United States

$0.0736 - $10.5530
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Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Combination drugs

( acetaminophen (tylenol), caffeine, butalbital (fiornal) - other name: esgic-plus )
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( caffeine, ergotamine - other names: migergot, wigraine )
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( caffeine, acetylsalicylic acid (aspirin), propoxyphene (Darvon) - other names: compoun, propoxyphene compoun )
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( acetaminophen (tylenol), caffeine, dihydrocodeine - other names: synalgos-dc-a, trezix )
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( acetaminophen (tylenol), caffeine, codeine (Phenergan), butalbital (fiornal) - other names: butalbital; acetaminophen; caffeine; codeine, phrenilin with caffeine and codeine )
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( caffeine, acetylsalicylic acid (aspirin), butalbital (fiornal) - other name: lanorinal )
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( caffeine, acetylsalicylic acid (aspirin), orphenadrine hydrochloride (disipal) - other names: invagesic, invagesic forte, norgesic, orphengesic, orphengesic forte )
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1,3,7-trimethyl-2,6-dioxopurine | 1,3,7-trimethylpurine-2,6-dione | 1,3,7-trimethylxanthine | 1-methyltheobromine | 3,7-dihydro-1,3,7-trimethyl-1h-purin-2,6-dion | 7-methyltheophylline | acetaminophen mixture with caffeine and dipyrone | anhydrous caffeine | cafalgine | cafcit | cafeina | cafeína | caféine | caffeine | caffeine citrate | caffeine, citrated | caffeinum | citrated caffeine | coffein | coffeine | coffeinum | durvitan | guaranine | koffein | mateína | methyltheobromine | nodoz | nodoz caplets and chewable tablets | nymusa | orphenadrine caffeine | peyona | pro-plus | teína | thein | theine | yeast-vite | zanthine

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