Trial | NCT04637633  Report issue

Title

Topical Cyclosporine-A for Management of Epiphora
Topical Cyclosporine-A for Management of Epiphora in Eyes With Acquired Punctal Stenosis

  • Phase

    Phase 2/Phase 3

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    12
to investigate the clinical outcomes and tolerances of Cyclosporine A (CsA) in treating epiphora in eyes with acquired punctum stenosis
a prospective study included patients who were referred to our outpatient clinics in Farwanyia hospital, Kuwait during the period between July 2019 and January 2020, having symptomatic epiphora associated with severe acquired lower punctal stenosis. Patients were treated with topical 0.05% CsA on twice daily dose with topical preservative free artificial tears Q.I. D. Patients were followed up monthly for at least 3 months by epiphora grading, Fluorescein dye disappearance test (FDT) and evaluating the patient satisfaction
Study Started
Aug 15
2020
Primary Completion
Oct 30
2020
Study Completion
Nov 01
2020
Last Update
Nov 23
2020

Drug topical 0.05% CsA (Restasis®, Allergan Inc, Irvine, California)twice daily dose,

topical preservative free artificial tears Q.I. D.

  • Other names: preservative free artificial tears

Cyclosporine A Experimental

All patients were treated with topical 0.05% CsA (Restasis®, Allergan Inc, Irvine, California) on twice daily dose, in addition to the topical preservative free artificial tears Q.I. D.

Criteria 

Inclusion Criteria:

Adult patients of either sex
had a diagnosis of epiphora that persisted more than three months both indoors and outdoors
grade 0 punctal stenosis
did not adequately respond to artificial tears, topical corticosteroids and topical antibiotics or in whom corticosteroids were discontinued due to their side effects.

Exclusion Criteria:

congenital punctal obstruction
edematous puncti
allergic conjunctivitis
history of dacryocystitis,
inflammatory systemic diseases
any previous chemotherapy treatment, and local irradiation.
other causes of epiphora, lid laxity, entropion, and ectropion
lid malposition, canalicular or nasolacrimal sac or duct obstruction
previous eyelid or lacrimal drainage surgery
untreated conjunctivitis or blepharitis
No Results Posted