Title
Effect of Arterio-venous ECMO on Severe Sepsis and ARDS
The Immunoadsorption Effect of Arterio-venous ECMO in Refractory Septic Shock With ARDS Following Severe Lung Contusion
Phase
Phase 1/Phase 2Lead Sponsor
King Abdul Aziz Specialist HospitalStudy Type
InterventionalStatus
Completed No Results PostedIndication/Condition
Patients With Respiratory Failure and ShockedIntervention/Treatment
Meropenem Injection ...Study Participants
100To evaluate and compare the effect of immunoadsorption effect of A-V ECMO on course of sepsis weaning from inotropes, weaning from the ventilator, duration of ICU stays and effect on mortality rate in patients with septic shock and respiratory failure due to ARDS followed severe lung contusion.
100 patients with respiratory failure without improvement after 10 days ventilation due to development of VAP with ARDS, had >2 SOFA score and >6 CPIS score included in two groups 50 patients in each. Only patients of group B put on A-V ECMO while patients of group A continue on traditional way of management. Improvement of ARDS &VAP, weaning from ventilation, duration of ICU stays, improvement of one/all parameters of both SOFA and CPIS scores, morbidity and mortality recorded and compared within 14 days.
patients of both groups given meropenam 1 gram every 8 hours till we collect the sputum culture
Only patients of group B connected to A-V ECMO for two weeks
Group A continue on the same conventional way of management as mentioned above with conventional way of ventilation and broad spectrum antibiotics coverage
group B who connected to (A-VECMO).with venous access from femoral vien and arterial cannulation using the femoral artery
Inclusion Criteria: Those who had an age between 18-65 years old patients ventilated for more than 10 days with conscious level more than 8/15 on Glasgow Coma Scale Exclusion Criteria: pediatric patients below 18 years of age
