Trial | NCT04553705  Report issue

Title

Omega-3, Nigella Sativa, Indian Costus, Quinine, Anise Seed, Deglycyrrhizinated Licorice, Artemisinin, Febrifugine on Immunity of Patients With (COVID-19)
Impact of Different Treatment Modalities on Immunity Against COVID-19

  • Phase

    Phase 2/Phase 3

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    150
The first version of this preprint article is registered on the 4th of May 2020 under the digital object identifier of:10.31219/osf.io/u56fc.

COVID-19 infections virus spread worldwide and impact many countries with sever economical sequences. The effective antiviral medication or vaccination for the virus is unavailable until the present date and it takes months or years to discover the effective treatment or test the efficacy of the discovered treatment.

Based on these facts, the human immune system against the virus may have an effective role to regulate the infection and reduce the mortality rate among the infected patients. This proposed research article aims to explore the available medication/ natural supplementation to boost the immunity system of the patients against COVID-19 infections and reduce the mortality rate among infected patients. Methods: a proposed clinical trial will be carried out to investigate the effect of the different treatment modalities on the human immune system against COVID-19 infection.
Natural supplementations have many reported effects on the human health ranged from immunity boosting to effective antiviral effect. Omeg-3 as an example affect the human health by many mechanisms e.g. Anti-oxidant, immunity boosting agent. Moreover, Omega-3 exerts an antiviral effect on Flu virus by inhibiting influenza virus replication 1. On the other hand, black seed supplementation exerts a chelation effect on sickle cell anemia patients and inhibits Human Heme Metabolism 2. Moreover, black seed exerts an antiviral effect on the replication of old coronavirus and the expression of (TRP-genes) family 3. In addition, Omega-3 regulates the human immunity against bacterial and viral infections 4. During the past years, many natural sources exerts an antimalarial effect with perfect reported results 5.
Study Started
Sep 20
2020
Primary Completion
Nov 04
2020
Study Completion
Dec 04
2021
Last Update
Jul 19
2022

Drug Omega 3/Nigella Sativa Oil [omega-3 fatty acids (Omacor), nigella sativa]

Omega-3 supplementation 1000mg contains (300-400mg EPA & 200-300mg DHA) Nigella sativa supplementation (1g black seed oil contain 3% thymoquinone

Drug Omega 3/Nigella Sativa Oil/Indian Costus [omega-3 fatty acids (Omacor), nigella sativa, indian costus]

Omega-3 supplementation 1000mg contains (300-400mg EPA & 200-300mg DHA) Nigella sativa supplementation (1g black seed oil contain 3% thymoquinone Indian Costus supplements

Drug Omega 3/Nigella Sativa Oil/Quinine pills [omega-3 fatty acids (Omacor), nigella sativa, quinine (qualaquin)]

Omega-3 supplementation 1000mg contains (300-400mg EPA & 200-300mg DHA) Nigella sativa supplementation (1g black seed oil contain 3% thymoquinone Quinine supplementation (1g Quinine)

Drug Omega 3/Nigella Sativa Oil/Anise seed capsule [omega-3 fatty acids (Omacor), nigella sativa, anise]

Omega-3 supplementation 1000mg contains (300-400mg EPA & 200-300mg DHA) Nigella sativa supplementation (1g black seed oil contain 3% thymoquinone Anise seed supplementation (450mg anise seed)

Drug Omega 3/Nigella Sativa Oil/Deglycyrrhizinated Licorice [omega-3 fatty acids (Omacor), nigella sativa, licorice]

Omega-3 supplementation 1000mg contains (300-400mg EPA & 200-300mg DHA) Nigella sativa supplementation (1g black seed oil contain 3% thymoquinone Deglycyrrhizinated Licorice 800 mg

Drug Active Comparator

Standard protocol care of COVID-19 infection

Omega-3/thymoquinone supplementation Experimental

10 patients that will receive every 14-days Omega-3/thymoquinone supplementation (300-400mg EPA & 200-300mg DHA) (3% thymoquinone) per day for one month. In addition to the standard care

Omega-3/thymoquinone / Indian Costus supplementation Experimental

10 patients that will receive every 14-days Omega-3/thymoquinone supplementation (300-400mg EPA & 200-300mg DHA), (3% thymoquinone),(Indian Costus) per day for one month. In addition to the standard care

Omega-3/thymoquinone / Quinine pills Experimental

10 patients that will receive every 14-days Omega-3/thymoquinone supplementation (300-400mg EPA & 200-300mg DHA), (3% thymoquinone),(1g Quinine) per day for one month. In addition to the standard care

Omega-3/thymoquinone / Anise seed capsule Experimental

10 patients that will receive every 14-days Omega-3/thymoquinone supplementation (300-400mg EPA & 200-300mg DHA), (3% thymoquinone),(450mg anise seed) per day for one month. In addition to the standard care

Omega-3/thymoquinone / Deglycyrrhizinated Licorice Experimental

10 patients that will receive every 14-days Omega-3/thymoquinone supplementation (300-400mg EPA & 200-300mg DHA), (3% thymoquinone),(Deglycyrrhizinated Licorice 800 mg ) per day for one month. In addition to the standard care

Active Comparator: standard care Active Comparator

The standard protocol care for COVID-19 approved from ministry of health at Saudi arabia

Criteria 

Inclusion Criteria:

Symptomatic with respiratory or systemic symptoms
Positive nasopharyngeal swab for COVID-19
CT imaging showing viral pneumonia
Temperature 38°C
Respiratory rate < 25 /min
Oxygen saturation (pulse oximetry) >95%

Exclusion Criteria:

Pregnant or breast feeding
Hepatic failure Child-Pugh C
Negative swab test of (SARS)-(CoV-2)
Expected life is less than 24 hours
End-stage lung disease
No Results Posted