Trial | NCT04551300  Report issue

Title

A Phase 2 Study to Evaluate the Safety and Efficacy of VS-505(AP301) to Treat Hyperphosphatemia in Hemodialysis Patients
A Phase 2 Study to Evaluate the Safety and Efficacy of Escalated and Fixed Doses of VS-505(AP301) in Comparison With Sevelamer Carbonate to Treat Hyperphosphatemia in Chronic Kidney Disease Patients Receiving Hemodialysis

  • Phase

    Phase 2

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    158
A multi-center, open-label, parallel-design, active-controlled phase 2 study to evaluate the tolerability, safety and efficacy of various dosages of VS-505 compared with Sevelamer Carbonate when given orally with meal for 6 weeks to treat hyperphosphatemia in chronic kidney disease subjects receiving maintenance hemodialysis.
The main body of this study has 5 intervention arms, 4 VS-505 treatment arms of various dosage plus 1 active control arm of Sevelamer Carbonate, each consists 25 subjects. Prior to this main part, a dose escalating cohort of 25 subjects is added to evaluate the tolerability of VS-505 in Chinese patient population.
Study Started
Oct 13
2020
Primary Completion
Jun 30
2022
Study Completion
Oct 15
2022
Last Update
Oct 18
2022

Drug VS-505

4 dosages of experimental drug

Drug Sevelamer Carbonate

Active Comparator

  • Other names: Renvela

VS-505 500mg Experimental

VS-505 500mg (two 250 mg capsules) oral administration three times a day with meal, daily total dosage 1500mg.

VS-505 750mg Experimental

VS-505 750mg (one 750 mg capsule) oral administration three times a day with meal, daily total dosage 2250mg.

VS-505 1500mg Experimental

VS-505 1500mg (two 750 mg capsules) oral administration three times a day with meal, daily total dosage 4500mg.

VS-505 2250mg Experimental

VS-505 2250mg (three 750 mg capsules) oral administration three times a day with meal, daily total dosage 6750mg.

Sevelamer Carbonate 1600mg Active Comparator

Sevelamer Carbonate 1600mg (two 800mg pills) oral administration three times a day with meal, daily total dosage 4800mg.

Criteria 

Inclusion Criteria:

Adults with end stage renal disease who are receiving a stable hemodialysis regimen (3 times per week) with sufficient dialysis adequacy;
Serum phosphorus level range from >1.94 mmol/L (6.0 mg/dL) to ≤3.23 mmol/L (10.0 mg/dL) at the end of washout phase.

Exclusion Criteria:

Kidney transplant patient or scheduled kidney transplant, or change to peritoneal dialysis, home hemodialysis or plan to relocate to another dialysis center during the study period；
Serum phosphorus level is <1.29 mmol/L（4.0 mg/dL) or >2.42 mmol/L（7.5 mg/dL) at screening, or documented to be >3.23 mmol/L（10 mg/dL) within the latest three month prior to screening (screening included);
Serum calcium level is <8 mg/dL or >11 mg/dL at the screening;
Serum immunoreactive parathyroid hormone (iPTH)>1000 pg/mL at the screening;
History of hemochromatosis or serum ferritin value ≥1000 μg/L at screening；
Current clinically significant gastrointestinal (GI) disorder, or history of intestine obstruction, gastrectomy or duodenectomy, or GI tract surgery within 12 weeks prior to screening;
Poorly controlled hypertension, cardiovascular disorders, and history of cerebrovascular disease or cardiovascular disease event within 24 weeks (6 months) prior to screening.
No Results Posted