Trial | NCT04441112  Report issue

Official Title

Intraarticular Injections of the Hip and Knee With Triamcinolone Versus Ketorolac: A Randomized Controlled Trial

  • Phase

    Phase 2/Phase 3

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    120
Clinicians commonly utilize intraarticular injections to treat symptomatic primary arthritis. Steroid injections are common yet have immune-modulating effects and can alter gene expression which may delay definitive arthroplasty and further damage cartilage. Non-steroidal anti-inflammatory (NSAID) injections may offer a safer profile due to their differing mechanism of action; however, there is a relative dearth of information regarding their efficacy. This non-inferiority study compares the effectiveness of triamcinolone versus ketorolac in treating symptoms of moderate to advanced primary osteoarthritis of the hip and knee.
Study Started
May 20
2018
Primary Completion
Aug 20
2019
Study Completion
Aug 20
2019
Last Update
Jun 22
2020

Drug Ketorolac Intraarticular Injection

Injections will be given under ultrasound guidance with one of two possible medications.

Drug Triamcinolone Intraarticular Injection

Injections will be given under ultrasound guidance with one of two possible medications.

Ketorolac Intraarticular Hip Injection Experimental

Patients will receive an intraarticular hip injection with ketorolac.

Triamcinolone Intraarticular Hip Injection Active Comparator

Patients will receive an intraarticular hip injection with triamcinolone.

Ketorolac Intraarticular Knee Injection Experimental

Patients will receive an intraarticular knee injection with ketorolac.

Triamcinolone Intraarticular Knee Injection Active Comparator

Patients will receive an intraarticular knee injection with triamcinolone.

Criteria 

Inclusion Criteria:

Symptomatic, radiographically proven degenerative joint disease in the hip or knee

Exclusion Criteria:

recent injection in the hip or knee within the previous 3 months
history of traumatic osteoarthritis or ligamentous reconstruction
chronic narcotic use
history of inflammatory or neuropathic arthropathy
pregnant and/or nursing women
allergy or strong reaction to study medications
No Results Posted