Official Title
Effect of Metformin on Gut Microbiota Changes and Glycemic Control of Newly Diagnosed Type 2 Diabetes
Phase
Phase 4Lead Sponsor
Shenzhen UniversityStudy Type
InterventionalStatus
Completed No Results PostedIndication/Condition
Type 2 DiabetesIntervention/Treatment
Metformin HydrochlorideStudy Participants
52This study was aimed to investigate the effect of metformin on the gut microbiota and glycemic control in newly diagnosed type 2 diabetes patients.
This study was aimed to investigate the effect of metformin on the gut microbiota and glycemic control in newly diagnosed type 2 diabetes patients. All the recurited patients were treated with metformin 1500-2000mg daily for 3 months. Stool specimens and blood samples were collected at the beginning and 3 months later.
treated with metformin 1500-2000mg daily
all the patients were treated with metformin 1500-2000mg daily for 3 months.
Inclusion Criteria: newly diagnosis type 2 diabetes ,HbA1c >7 % Exclusion Criteria: history of cardiovascular disease, hypertension, severe renal dysfunction defined as glomerular filtration rate < 45 mL/min/1.73 m2; severe illness or diabetic ketoacidosis within 30 days, inability to tolerate ≥500 mg metformin twice per day and pregnancy.