Clinical Drug Experience Knowledgebase

Criteria

Inclusion Criteria:

Willing and able to participate in the study and provide written informed consent
Be ≥ 18 years of age on the day of signing the Informed Consent Form

Patients must have thyroid cancer that expresses ICAM-1 and that meets one of the following diagnoses:

Anaplastic Thyroid Cancer BRAF wild-type at any stage, including newly diagnosed
Anaplastic Thyroid Cancer BRAF mutant after failure of or inability to tolerate BRAF- specific therapy
Poorly Differentiated Thyroid Cancer that has failed any of the following treatments: surgery radioactive iodine, chemotherapy, radiation therapy, and/or targeted therapies

Measurable disease by Computed Tomography (CT) or Positron Emission Tomography (PET) PET/CT per RECIST v1.1

a. For ATC patients who do not have measurable disease at Screening, they are required to have measurable disease at Baseline Day -7 to proceed in the study.

Eastern Cooperative Oncology Group (ECOG) performance status 0 to 2
Life expectancy greater than 8 weeks

Overall adequate hepatic, renal, bone marrow, cardiac, and coagulation function, defined as the following:

Estimated creatinine clearance ≥ 50 mL/minute
Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST): normal or Grade 1. Note: Lymphodepleting Chemotherapy (LDC) agents can cause fluctuations in hepatic enzymes.
Serum total bilirubin: normal or Grade 1. Note: LDC agents can cause fluctuations in hepatic enzymes.
Serum albumin: normal or Grade 1. (human albumin supplementation is not allowed within 2 weeks prior to Screening assessment)
Hemodynamically stable and left ventricular ejection fraction ≥ 45%
Hematological parameters

i. Absolute neutrophil count > 1000/μL without myeloid growth factor support for ≥ 2 weeks

ii. Absolute lymphocyte count ≥ 100/μL at screening and at apheresis

iii. Platelet count ≥ 50 × 1000/μL without platelet transfusion for ≥ 2 weeks

iv. Hemoglobin concentration > 8 g/dL without red blood cell transfusion for ≥ 2 weeks

Has met the minimum washout time for previous cancer treatments before undergoing apheresis or LDC, and in the Investigator's judgement, the patient is able to safely undergo the procedure
(incorporated into inclusion criterion #7)
Females of reproductive potential (defined as all females physiologically capable of becoming pregnant) must agree to use 1 highly effective method of contraception and 1 additional effective method from at least 28 days before enrollment/apheresis and for at least 1 year after the infusion of AIC100 CAR T Cells.
Females of reproductive potential must have a negative serum beta-human chorionic gonadotropin pregnancy test result at Screening
(incorporated into inclusion criterion #3)

Exclusion Criteria:

Women who are pregnant or breastfeeding

Clinically significant, active, uncontrolled, systemic infection; the following are not exclusionary:

Patients with HIV must have been on effective antiretroviral therapy for ≥ 4 weeks prior to enrollment; must have an HIV viral load < 400 copies/µL; no acquired immunodeficiency syndrome related opportunistic infections in the previous 12 months; and a CD4+ cell count ≥ 350 cells/µL
Patients with chronic hepatitis B virus (HBV) infection must be on antiviral therapy and have an HBV viral load below the limits of detection
Patients with chronic hepatitis C virus (HCV) infection must have completed therapy and have an HCV viral load below the limits of detection
Prior treatment with investigational gene therapy or CAR T cell therapy
Presence of active and clinically relevant central nervous system disorder such as epilepsy, stroke, or symptomatic or uncontrolled brain metastases
Evidence of another malignancy within 2 years prior to Screening (except in-situ non melanoma skin cancers, localized controlled prostate cancer, adequately treated Stage 1 uterine cancer that has a low risk of recurrence, or any other malignancies with similar outcome)
(incorporated into exclusion criterion #2)
Active autoimmune disease (including but not limited to systemic lupus erythematosus, Sjögren's Syndrome, rheumatoid arthritis (RA), psoriasis, multiple sclerosis, inflammatory bowel disease) requiring immunosuppressive therapy within 4 weeks prior to eligibility confirmation
Patients with severe chronic diseases of the kidney, liver, heart, lung; or any other serious illness that, in the opinion of the Investigator, may affect the patient's treatment, follow up, or assessments, including but not limited to uncontrolled clinically significant neurological or psychiatric disorders or metabolic diseases
Patients who need long-term use of systemic corticosteroids > 10 mg/day prednisone or equivalent
Allergy to any of the chemotherapy drugs given during lymphodepletion or known hypersensitivity to any component of AIC100 CAR T Cells, including excipients
Receipt of a COVID-19 vaccine within 4 weeks before Screening

Concurrent participation in another interventional clinical study during participation in this study

Prior treatment with any gene therapy or genetically modified cell therapy, including CAR T cells
Prior treatment with ICAM-1 directed antibody, bispecific T cell engager, or antibody drug conjugate, unless there is confirmed ICAM-1 expression (by immunohistochemistry) after progression or relapse following most recent ICAM-1 directed treatment.