Trial | NCT04342065  Report issue

Title

Pregabalin Versus Celecoxib on Sevoflurane and Analgesic Consumption in Spine Fixation Surgery
Efficacy of Pre-emptive Different Doses of Oral Pregabalin Versus Celecoxib on Sevoflurane and Analgesic Consumption in Patients Subjected for Elective Lumbar Spine Fixation Surgery: a Randomized Controlled Trial

  • Phase

    Phase 2/Phase 3

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    200
The anti-epileptic drugs such as gabapentin and other non-steroidal anti-inflammatory drugs (NSAID) such as celecoxib were used as a part of multimodal analgesia to control such pain. Gabapentin is an anticonvulsant drug that has analgesic effect in post-herpetic neuralgia, diabetic neuropathy, and neuropathic pain. Celecoxib is one of the NSAIDs, that its analgesic effect is reported in various studies by cyclooxygenase-2 (COX-2) inhibitor.

The aim of this randomized double-blinded study was to asses and compare the efficacy of using gabapentin versus celecoxib as a part of multimodal analgesia in perioperative hemodynamic control and pain relief in patients underwent posterior approach lumbar spine disc fixation surgery.
Study Started
Jan 01
2019
Primary Completion
Jan 30
2020
Study Completion
Feb 01
2020
Last Update
Apr 14
2020

Drug Celecoxib capsules

received celecoxib 200 mg 2 hours preoperative and the same dose 6 hours postoperative.

Drug Pregabalin 150mg

received Pregabalin 150mg 2 hours preoperative and the same dose 6 hours postoperative.

Group (G) Active Comparator

received gabapentin 300 mg capsule 2 hours preoperative and the same dose 6 hours postoperative.

Group (C) Active Comparator

received celecoxib 200 mg 2 hours preoperative and the same dose 6 hours postoperative.

Criteria 

Inclusion Criteria:

American society of anesthesiologists (ASA) I and II, aged between 21-60 years old scheduled to undergo elective posterior approach lumbar spine disc surgery

Exclusion Criteria:

Patients with a known sensitivity to celecoxib or pregabalin, psychotic disorder or cognitive impairment, history of drug dependency or substance addiction, history of chronic medical disease, the presence of coagulation disorders or pregnancy, were excluded from the study.
No Results Posted