Title
Intervention With a GABA Supplement in Prediabetics
The Effects of a GABA Supplement Versus a Placebo on Glucose Tolerance and Blood Pressure in Prediabetics
Phase
N/ALead Sponsor
Wageningen UniversityStudy Type
InterventionalStatus
Completed No Results PostedIndication/Condition
Prediabetes HypertensionIntervention/Treatment
GABA ...Study Participants
52In this double-blind parallel placebo controlled intervention study the effects of 3 times daily 500 mg gamma-aminobutyric acid (GABA) supplementation on glucose tolerance and cardiovascular health will be assessed in prediabetics.
The dietary supplement GABA will be taken orally 3 times daily, before each main meal
Gelatin capsule containing powdered cellulose
GABA is a nutrient commonly present in our diet in for example tomatoes and potatoes. It is also commercially sold as dietary supplement. A dose of 500 mg, 3 times daily is used
The placebo consists of capsules containing powdered cellulose.
Inclusion Criteria: Age between 50 and 70 BMI higher or equal to 27 kg/m2 Impaired fasting glucose (fasting glucose ≥ 6.1 and ≤ 6.9 mmol/L) or/and Impaired glucose tolerance (glucose levels ≥ 7.8 and ≤ 11.1 mmol/L, 2-hours after an OGTT or/and glucose levels ≥8.6 mmol/L, 1-hour after an OGTT) Exclusion Criteria: Has been diagnosed with diabetes Having other conditions, like liver, pancreatic, cardiovascular, gastro-intestinal or endocrine diseases, that could influence the study results Use of medications or supplements that could influence the study results Sensitive to medical skin adhesives More than 5kg weight change in the past 12 weeks Excessive alcohol consumption (>21 glasses/week for men and >14 glasses/week for women on average) Being an employee of Wageningen University, division Human Nutrition and Health Currently a research subject in other research
