Trial | NCT04120870  Report issue

Title

Comparison of Ketamine and Etomidate During Rapid Sequence Intubation in Trauma Patients
Comparison of Effects on Hemodynamics Between Ketamine and Etomidate During Rapid Sequence Intubation in Trauma Patients With High Shock Index

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Terminated

  • Study Participants

    10
In trauma patients with high shock index, the investigators compare the effects on hemodynamics between ketamine and etomidate.
In trauma patients, rapid sequence intubation is recommended. The drug of choice, however, has been debated. One cohort comparative study showed ketamine had benefit in hemodynamics compared to etomidate in trauma patients. One observational study showed in high shock index patients, ketamine showed maintain systolic blood pressure. And other retrospective showed less clinical hypotension was less in ketamine. However there is no randomized controlled study comparing ketamine and etomidate in trauma patients. The purpose of this study is comparing the effects of hemodynamics between ketamine and etomidate in high shock index trauma patients.
Study Started
Oct 01
2019
Primary Completion
Nov 30
2021
Study Completion
Dec 30
2021
Last Update
Mar 03
2022

Drug Etomidate Injection 0.2 mg/kg

The induction agent of rapid sequence intubation is etomidate. 0.2 mg/kg

  • Other names: Etomidate

Drug Ketamine injection 2 mg/kg

The induction agent of rapid sequence intubation is ketamine. 2 mg/kg

  • Other names: Ketamine

Etomidate Active Comparator

The induction agent of rapid sequence intubation is etomidate. 0.2 mg/kg

Ketamine Experimental

The induction agent of rapid sequence intubation is ketamine. 2 mg/kg

Criteria 

Inclusion Criteria:

age 19~70
Shock index ≥ 0.9
Patients who need intubation regarding to Ajou trauma center protocol

Exclusion Criteria:

during CPR
CPR before hospital arrival
Severe head trauma
Steroid intake history
No Results Posted