Trial | NCT04051567  Report issue

Title

Low-dose Aspirin for Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies
Low-dose Aspirin for Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies--A Multicenter, Prospective, Open, Randomized, Controlled Clinical Trial

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Unknown status

  • Study Participants

    425
Twin pregnancies are associated with increased risk of perinatal adverse outcomes , including preeclampsia , fetal growth restriction , preterm premature rupture of membranes and preterm birth. Low-dose aspirin was recommend by American College of Obstetricians and Gynecologists (ACOG) during pregnancy. In this trial, the investigators suppose that aspirin used in twin-pregnancies could improve adverse pregnancy outcomes.
Study Started
Nov 01
2018
Primary Completion
Jun 01
2020
Anticipated
Study Completion
Dec 01
2020
Anticipated
Last Update
Oct 29
2019

Drug Aspirin 100mg

In LDA group, patients were asked for taking 100mg aspirin per night;

LDA group Experimental

NC group No Intervention

Criteria 

Inclusion Criteria:

Twin pregnancy diagnosed by ultrasound and maternal age ranged from 18 to 55 years, Gestational age was less than 16w

Exclusion Criteria:

Diagnosed fetal anomalies, history of cervical cerclage, contraindications of aspirin, pre-existing renal or liver diseases or abnormal functions, coagulation disorders, history of PE, preterm birth or FGR, chronic hypertension
No Results Posted